PML RARA bcr1 and bcr3 Screening Kit

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PML RARA bcr1 and bcr3 Detection Kit

Historically, Acute promyelocytic leukemia (APL or AML-M3) is one of the most lethal forms of acute myeloid leukemia with distinct clinical and histopathologic features.

Acute promyelocytic leukemia is characterized by a unique chromosomal translocation involving the retinoic acid receptor-alpha gene on chromosome 17 (RARA). In greater than 99% of cases of APL, retinoic acid receptor-alpha (RARA) gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q12)

Depending on the location of breakpoints within the PML site, intron 6, exon 6 and intron 3, the respective PML-RARa transcript subtypes referred to as long (L or bcr1), variant (V or bcr2) and short (S or bcr3), may be formed representing 55%, 5% and 40% of the cases respectively. The presence of PML/RARA t(15;17) translocation is necessary for response to all-trans-retinoic acid and arsenic trioxide. Thus, the PML/RARA t(15;17) assay is useful for diagnosis and predicting treatment response. It is also helpful for monitoring therapeutic response and MRD and for detecting early relapse.

PML RARA bcr1 and bcr3 Detection Kit Features

Easy workflow with ready-to-use solutions for “Direct to customer” clinical lab tests
Detection of the PML/RARA t(15;17) (q21;q22) translocation
a tool to detect for Acute promyelocytic leukemia (APL or AML-M3)
Real-time quantitative gene analysis of control gene and fusion gene transcript bcr1 (PMLex6/RAR ex3L-form (=BCR1) ) and fusion gene transcript bcr3 (PMLex6/RAR ex3S-form (=BCR3))
One-step High Performance quantitative detection – no need to perform separate cDNA synthesis and qPCR
Results aligned with control standards included with the kit.
Low contamination risk – no post-PCR product handling
Fast – results in under 80 minutes after PCR start
Multiplexed – Control and target genes assessed in the same reaction
Includes all the reagent required to perform RNA to Result analysis no additional reagents needed. (Including Mastermix)

PML RARA bcr1 and bcr3 Detection Kit Contents

Order Information for PML RARA bcr1 and bcr3 Detection Kit

#	Product	Cat. No.	Reaction size/kit
1	Oncoscreen PML RARA bcr1 Quantitative PCR kit	OPLQ25	25
2	Oncoscreen PML RARA bcr1 Quantitative PCR kit	OPLQ50	50
3	Oncoscreen PML RARA bcr1 and bcr3 Quantitative PCR kit	OPLSQ25	25
4	Oncoscreen PML RARA bcr1 and bcr3 Quantitative PCR kit	OPLSQ50	50
5	Oncoscreen PML RARA bcr1 and bcr3 Quantitative PCR kit	OPLSQ100	100

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