Hepatitis C virus (HCV) is a leading cause of chronic liver disease (CLD) that can progress to Cirrhosis and hepatocellular carcinoma. HCV genotyping constitutes the basis for the clinical management of infected patients by providing a predictor of response to therapy and to decide on the length of time required for antiviral treatment. HCV is classified into six major genotypes (1- 6), many subtypes (a, b, c, etc.), based on the genomic sequence heterogeneity. HCV 1 and genotype 3 are found to be the predominant genotypes in the Indian sub-continent. Genotype 1 and 4 are generally associated with a poor response to interferon alone, whereas genotypes 2 and 3 are associated with more favourable responses.