Human leukocyte antigen (HLA) B27 is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6. The human leucocyte antigen (HLA) B*27 is strongly associated with the spondyloarthropathies (SpA’s).
HLA-B*27 is found in 90-95% of ankylosing spondylitis (AS) patients and also lesser frequency in forms of psoriatic arthritis and reactive arthritis. HLA-B*27 may have a direct role in the pathogenesis of SpA. There are more than 50 subtypes of HLA-B27 identified which mostly differ by only a small number of nucleotides. Allele specific PCR offers excellent specificity and sensitivity for HLA-B*27 genotype.
Mylab Lifesolutions HLAB*27 Detection test is an in vitro diagnostic test for the detection of HLAB*27 genotypes as an aid to diagnosis in the evaluation of patients with suspected ankylosing spondylitis by allele specific real time PCR.